MpMRI preoperative staging in men treated with antiandrogen and androgen deprivation therapy before robotic prostatectomy.

ABSTRACT:

Introduction

Using multiparametric magnetic resonance imaging (mpMRI), we sought to preoperatively characterize prostate cancer (PCa) in the setting of antiandrogen plus androgen deprivation therapy (AA-ADT) prior to robotic-assisted radical prostatectomy (RARP). We present our preliminary findings regarding mpMRI depiction of changes of disease staging features and lesion appearance in treated prostate.

Methods

Prior to RARP, men received 6 months of enzalutamide and goserelin. mpMRI consisting of T2 weighted, b = 2,000 diffusion weighted imaging, apparent diffusion coefficient mapping, and dynamic contrast enhancement sequences was acquired before and after neoadjuvant therapy. Custom MRI-based prostate molds were printed to directly compare mpMRI findings to H&E whole-mou

SUBMITTER: Gold SA 

PROVIDER: S-EPMC8132295 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature