Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment.

ABSTRACT:

Background

Serotonin signaling has been associated with tumorigenesis and tumor progression. Targeting the serotonin transporter to block serotonin cellular uptake confers antineoplastic effects in various tumors, including colon cancer. However, the antineoplastic mechanism of serotonin transporter inhibition and serotonin metabolism alterations in the absence of serotonin transporter have not been elucidated, especially in colon cancer, which might limit anti-tumor effects associating with targeting serotonin transporter.

Methods

The promotion in the uptake and catabolism of extracellular tryptophan and targeting serotonin transporter was detected by using quantitative reverse-transcription polymerase chain reaction, western blotting and liquid chromatography tandem mass s

SUBMITTER: Ye D 

PROVIDER: S-EPMC8132442 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature