Simulating within host human immunodeficiency virus 1 genome evolution in the persistent reservoir.

ABSTRACT: The complexities of viral evolution can be difficult to elucidate. Software simulating viral evolution provides powerful tools for exploring hypotheses of viral systems, especially in situations where thorough empirical data are difficult to obtain or parameters of interest are difficult to measure. Human immunodeficiency virus 1 (HIV-1) infection has no durable cure; this is primarily due to the virus' ability to integrate into the genome of host cells, where it can remain in a transcriptionally latent state. An effective cure strategy must eliminate every copy of HIV-1 in this 'persistent reservoir' because proviruses can reactivate, even decades later, to resume an active infection. However, many features of the persistent reservoir remain unclear, including the temporal dynamics of HIV

SUBMITTER: Jones BR 

PROVIDER: S-EPMC8132731 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature