General anaesthesia during infancy reduces white matter micro-organisation in developing rhesus monkeys.

ABSTRACT:

Background

Non-human primates are commonly used in neuroimaging research for which general anaesthesia or sedation is typically required for data acquisition. In this analysis, the cumulative effects of exposure to ketamine, Telazol® (tiletamine and zolazepam), and the inhaled anaesthetic isoflurane on early brain development were evaluated in two independent cohorts of typically developing rhesus macaques.

Methods

Diffusion MRI scans were analysed from 43 rhesus macaques (20 females and 23 males) at either 12 or 18 months of age from two separate primate colonies.

Results

Significant, widespread reductions in fractional anisotropy with corresponding increased axial, mean, and radial diffusivity were observed across the brain as a result of repeated anaesthesia exposu

SUBMITTER: Young JT 

PROVIDER: S-EPMC8132881 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature