A synthetic pathogen mimetic molecule induces a highly amplified synergistic immune response via activation of multiple signaling pathways.
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ABSTRACT:
SUBMITTER: Nihesh N
PROVIDER: S-EPMC8132936 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
A synthetic pathogen mimetic molecule induces a highly amplified synergistic immune response <i>via</i> activation of multiple signaling pathways.
Nihesh Naorem N Manna Saikat S Studnitzer Bradley B Shen Jingjing J Esser-Kahn Aaron P AP
Chemical science 20210401 19
The current understanding of how the immune system processes complex information during natural infections is yet to be exploited for the molecular design of potent immune activators. Here, we address this challenge by design of a pathogen-mimetic molecule that simultaneously co-activates cell-surface active, endosomal and cytosolic immune receptors. ...[more]
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