Gastric Mucosal Immune Profiling and Dysregulation in Idiopathic Gastroparesis.

ABSTRACT:

Introduction

It is unclear how immune perturbations may influence the pathogenesis of idiopathic gastroparesis, a prevalent functional disorder of the stomach which lacks animal models. Several studies have noted altered immune characteristics in the deep gastric muscle layer associated with gastroparesis, but data are lacking for the mucosal layer, which is endoscopically accessible. We hypothesized that immune dysregulation is present in the gastroduodenal mucosa in idiopathic gastroparesis and that specific immune profiles are associated with gastroparesis clinical parameters.

Methods

In this cross-sectional prospective case-control study, routine endoscopic biopsies were used for comprehensive immune profiling by flow cytometry, multicytokine array, and gene expression i

SUBMITTER: Gottfried-Blackmore A 

PROVIDER: S-EPMC8132986 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature