Controllable double CF₂-insertion into sp² C-Cu bond using TMSCF₃: a facile access to tetrafluoroethylene-bridged structures.

ABSTRACT: A highly efficient method for controllable double CF₂-insertion into pentafluorophenylcopper species using TMSCF₃ as difluoromethylene source has been developed. The newly generated fluoroalkylcopper(i) species, C₆F₅CF₂CF₂Cu, shows good reactivity towards a myriad of structurally diverse aryl, heteroaryl and alkenyl iodides. This protocol is easy to handle, ready to scale up and applicable for the synthesis of relative complex molecules, thus providing a convenient method for facile access to tetrafluoroethylene-bridged structures.

SUBMITTER: Xie Q 

PROVIDER: S-EPMC8133001 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature