Ontology highlight
ABSTRACT:
SUBMITTER: Alatrash N
PROVIDER: S-EPMC8133002 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Alatrash Nagham N Issa Faiza H FH Bawazir Nada S NS West Savannah J SJ Van Manen-Brush Kathleen E KE Shelor Charles P CP Dayoub Adam S AS Myers Kenneth A KA Janetopoulos Christopher C Lewis Edwin A EA MacDonnell Frederick M FM
Chemical science 20191118 1
Treatment of malignant and non-malignant cultured human cell lines with a cytotoxic IC<sub>50</sub> dose of ∼2 μM tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(ii) chloride (<b>RPC2</b>) retards or arrests microtubule motion as tracked by visualizing fluorescently-tagged microtubule plus end-tracking proteins. Immunofluorescent microscopic images of the microtubules in fixed cells show substantial changes to cellular microtubule network and to overall cell morphology upon treatment with <b>RPC ...[more]