Impact of Duration of N-Acetylcysteine in Non-Acetaminophen-Induced Acute Liver Failure.

ABSTRACT:

Objectives

Studies of the use of IV N-acetylcysteine in the management of non-acetaminophen-induced acute liver failure have evaluated various dosing regimens. The only randomized trial studying this application described a 72-hour regimen. However, observational studies have reported extended duration until normalization of international normalized ratio. This study seeks to compare differences in patient outcomes based on IV N-acetylcysteine duration.

Design

Retrospective cohort study.

Setting

Medical ICU at a large quaternary care academic medical institution and liver transplant center.

Patients

Adult patients admitted to the medical ICU who received IV N-acetylcysteine for the treatment of non-acetaminophen-induced acute liver failure.

Interventions

SUBMITTER: Bass SN 

PROVIDER: S-EPMC8133178 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature