The Antifungal Activity of HMA, an Amiloride Analog and Inhibitor of Na⁺/H⁺ Exchangers.

ABSTRACT: One path toward identifying effective and easily accessible antifungals is to repurpose commonly used drugs. Amiloride, a widely used diuretic, inhibits different isoforms of Na⁺/H⁺ exchangers, Na⁺ channels, and Na⁺/Ca²⁺ exchangers. Here, we found that amiloride had poor antifungal activity against isolates of Cryptococcus prompting the examination of the amiloride analog, HMA [5-(N,N-hexamethylene)amiloride]. HMA possesses strong activity against Na⁺/H⁺ exchangers (NHEs) and little K⁺-associated toxicity since HMA has only minimal inhibitory effects toward epithelial sodium channels (ENaC), the diuretic and antikaliuretic target of amiloride. Although HMA produced a robust dose-dep

SUBMITTER: Vu K 

PROVIDER: S-EPMC8133316 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature