Bilateral Subthalamic Nucleus Deep Brain Stimulation in Elderly Patients With Parkinson Disease: A Case-Control Study.

ABSTRACT:

Background

Subthalamic nucleus deep brain stimulation (STN DBS) is an effective adjunctive therapy for Parkinson disease. Studies have shown improvement of motor function but often exclude patients older than 75 yr.

Objective

To determine the safety and effectiveness of STN DBS in patients 75 yr and older.

Methods

A total of 104 patients (52 patients >75 yr old, 52 patients <75 yr old) with STN DBS were paired and retrospectively analyzed. The primary outcome was change in Unified Parkinson Disease Rating Scale (UPDRS) subscale III at 1 yr postoperatively, OFF medication. Secondary outcomes were changes in UPDRS I, II, and IV subscales and levodopa equivalents. Complications and all-cause mortality were assessed at 30 d and 1 yr.

Results

Both cohorts had signif

SUBMITTER: Mitchell KT 

PROVIDER: S-EPMC8133356 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature