Incidence of hyperkalemia during hypertonic saline test for the diagnosis of diabetes insipidus.

ABSTRACT:

Objective

Hyperkalemia has been reported upon different hypertonic saline infusion protocols. Since hypertonic saline test has recently been validated for the differential diagnosis of diabetes insipidus (DI), we aimed to investigate the course of plasma potassium during the test.

Design

We analyzed data of 90 healthy volunteers and 141 patients with polyuria-polydipsia syndrome (PPS) from two prospective studies evaluating the hypertonic saline test. Our primary outcome was the incidence rate of hypertonic saline-induced hyperkalemia > 5 mmol/L.

Methods

Participants received a 250 mL bolus of 3% NaCl solution, followed by 0.15 mL/min/kg body weight continuously infused targeting a plasma sodium level of 150 mmol/L. Blood samples and clinical data were collected every

SUBMITTER: Potasso L 

PROVIDER: S-EPMC8133371 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature