Long-term opiate use and risk of cardiovascular mortality: results from the Golestan Cohort Study.

ABSTRACT:

Aims

Tens of millions of people worldwide use opiates but little is known about their potential role in causing cardiovascular diseases. We aimed to study the association of long-term opiate use with cardiovascular mortality and whether this association is independent of the known risk factors.

Methods and results

In the population-based Golestan Cohort Study-50 045 Iranian participants, 40-75 years, 58% women-we used Cox regression to estimate hazard ratios and 95% confidence intervals (HRs, 95% CIs) for the association of opiate use (at least once a week for a period of 6 months) with cardiovascular mortality, adjusting for potential confounders-i.e. age, sex, education, wealth, residential place, marital status, ethnicity, and tobacco and alcohol use. To show independent

SUBMITTER: Nalini M 

PROVIDER: S-EPMC8133380 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature