Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.

ABSTRACT: The immune and enteric nervous (ENS) systems monitor the frontier with commensal and pathogenic microbes in the colon. We investigated whether FoxP3⁺ regulatory T (Treg) cells functionally interact with the ENS. Indeed, microbe-responsive RORγ⁺ and Helios⁺ subsets localized in close apposition to nitrergic and peptidergic nerve fibers in the colon lamina propria (LP). Enteric neurons inhibited in vitro Treg (iTreg) differentiation in a cell-contact-independent manner. A screen of neuron-secreted factors revealed a role for interleukin-6 (IL-6) in modulating iTreg formation and their RORγ⁺ proportion. Colonization of germfree mice with commensals, especially RORγ⁺ Treg inducers, broadly diminished colon neuronal density. Closing the tri

SUBMITTER: Yan Y 

PROVIDER: S-EPMC8133394 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature