Available medications used as potential therapeutics for COVID-19: What are the known safety profiles in pregnancy.

ABSTRACT:

Background

Medications already available to treat other conditions are presently being studied in clinical trials as potential treatments for COVID-19. Given that pregnant women are excluded from these trials, we aimed to investigate their safety when used during pregnancy within a unique population source.

Methods

Using the population-based Quebec Pregnancy Cohort, we identified women who delivered a singleton liveborn (1998-2015). Taking potential confounders into account including indications for use, the risk of prematurity, low birth weight (LBW), small for gestational age (SGA), and major congenital malformation (MCM) associated with COVID-19 repurposed drug use during pregnancy were quantified using generalized estimation equations.

Results

Of the 231,075 eligi

SUBMITTER: Berard A 

PROVIDER: S-EPMC8133446 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature