Ontology highlight
ABSTRACT:
SUBMITTER: Munafo M
PROVIDER: S-EPMC8133776 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Munafò Marzia M Lawless Victoria R VR Passera Alessandro A MacMillan Serena S Bornelöv Susanne S Haussmann Irmgard U IU Soller Matthias M Hannon Gregory J GJ Czech Benjamin B
eLife 20210415
The nuclear pore complex (NPC) is the principal gateway between nucleus and cytoplasm that enables exchange of macromolecular cargo. Composed of multiple copies of ~30 different nucleoporins (Nups), the NPC acts as a selective portal, interacting with factors which individually license passage of specific cargo classes. Here we show that two Nups of the inner channel, Nup54 and Nup58, are essential for transposon silencing via the PIWI-interacting RNA (piRNA) pathway in the <i>Drosophila</i> ova ...[more]