Reduced purine biosynthesis in humans after their divergence from Neandertals.
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ABSTRACT:
SUBMITTER: Stepanova V
PROVIDER: S-EPMC8133780 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Reduced purine biosynthesis in humans after their divergence from Neandertals.
Stepanova Vita V Moczulska Kaja Ewa KE Vacano Guido N GN Kurochkin Ilia I Ju Xiangchun X Riesenberg Stephan S Macak Dominik D Maricic Tomislav T Dombrowski Linda L Schörnig Maria M Anastassiadis Konstantinos K Baker Oliver O Naumann Ronald R Khrameeva Ekaterina E Vanushkina Anna A Stekolshchikova Elena E Egorova Alina A Tkachev Anna A Mazzarino Randall R Duval Nathan N Zubkov Dmitri D Giavalisco Patrick P Wilkinson Terry G TG Patterson David D Khaitovich Philipp P Pääbo Svante S
eLife 20210504
We analyze the metabolomes of humans, chimpanzees, and macaques in muscle, kidney and three different regions of the brain. Although several compounds in amino acid metabolism occur at either higher or lower concentrations in humans than in the other primates, metabolites downstream of adenylosuccinate lyase, which catalyzes two reactions in purine synthesis, occur at lower concentrations in humans. This enzyme carries an amino acid substitution that is present in all humans today but absent in ...[more]
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