Avoiding breast cancer surgery in a select cohort of complete responders to neoadjuvant chemotherapy: The long-term outcomes.

ABSTRACT:

Background

Lately, there has been a resurgence of interest in de-escalation of breast surgery in complete responders to neoadjuvant chemotherapy (NAC). Advanced cytotoxic & targeted therapies have improved tumour response.This study evaluates long-term outcomes of post-NAC breast cancer patients, in relation to their surgical management dictated by the NAC response.

Materials and methods

Post-NAC breast cancer patients from January 2000 to December 2010 were divided into "No surgery", "WLE" and "Mastectomy" groups. ANOVA and Kaplan-Meier statistical analyses were used to compare overall survival (OS) and disease-free-survival (DFS) in these groups.

Results

This retrospective study included 121 patients with a long median follow-up of 11.5 years. At 10 years the OS was

SUBMITTER: Apte A 

PROVIDER: S-EPMC8134025 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature