TP53 alterations of hormone-naive prostate cancer in the Chinese population.

ABSTRACT:

Background

Prostate cancer (PCa) shows racial disparity in clinical and genomic characteristics, and Asian patients with PCa often present with more aggressive phenotypes at diagnosis. The ability of TP53 to serve as a prognostic biomarker of PCa has been well studied in Western populations. However, no studies to date have examined the role of TP53 in the disparities of primary hormone-naïve prostate cancer (HNPC) between Chinese and Western populations.

Methods

We collected prostate tumors and matched normal tissues or blood samples to perform targeted next-generation sequencing of 94 Chinese primary localized HNPC samples, and correlated these genomic profiles with clinical outcomes. The OncoKB knowledge database was used to identify and classify actionable alterations.

SUBMITTER: Liu Z 

PROVIDER: S-EPMC8134057 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature