MRNA expression in rabbit experimental aneurysms: a study using gene chip microarrays.

ABSTRACT:

Background and purpose

The molecular characteristics of intracranial aneurysms are still poorly documented. A rabbit elastase aneurysm model has been helpful in the evaluation of devices and strategies involved in endovascular treatment of aneurysms. The goal of this project was to document the molecular changes, assessed by gene chip microarrays, associated with the creation of aneurysms in this model compared with the contralateral carotid artery.

Materials and methods

A microarray of rabbit genes of interest was constructed using rabbit nucleotide sequences from GenBank. Elastase-induced saccular aneurysms were created at the origin of the right common carotid artery in 4 rabbits. Twelve weeks after aneurysm creation, RNA was isolated from the aneurysm as well as the cont

SUBMITTER: Mangrum WI 

PROVIDER: S-EPMC8134323 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature