Larger dentate gyrus volume as predisposing resilience factor for the development of trauma-related symptoms.

ABSTRACT: Early interventions to improve resilience require the identification of objective risk biomarkers for PTSD symptom development. Although altered hippocampal and amygdala volumes are consistently observed in PTSD, it remains currently unknown whether they represent a predisposing vulnerability factor for PTSD symptom development or an acquired consequence of trauma exposure and/or the disorder. We conducted a longitudinal, prospective study in 210 police recruits at high risk for trauma exposure (56 females(26.7%); mean[SD] age = 24.02[5.19]). Structural MRI scans and trauma-related symptom severity were assessed at pre-trauma baseline and at 16-month follow-up. Between assessments, police recruits were exposed to various potentially traumatic events during their police training. Police rec

SUBMITTER: Koch SBJ 

PROVIDER: S-EPMC8134447 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature