Club cell-specific role of programmed cell death 5 in pulmonary fibrosis.
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ABSTRACT:
SUBMITTER: Park SY
PROVIDER: S-EPMC8134485 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Club cell-specific role of programmed cell death 5 in pulmonary fibrosis.
Park Soo-Yeon SY Hong Jung Yeon JY Lee Soo Yeon SY Lee Seung-Hyun SH Kim Mi Jeong MJ Kim Soo Yeon SY Kim Kyung Won KW Shim Hyo Sup HS Park Moo Suk MS Lee Chun Geun CG Elias Jack A JA Sohn Myung Hyun MH Yoon Ho-Geun HG
Nature communications 20210519 1
Idiopathic pulmonary fibrosis (IPF) causes progressive fibrosis and worsening pulmonary function. Prognosis is poor and no effective therapies exist. We show that programmed cell death 5 (PDCD5) expression is increased in the lungs of patients with IPF and in mouse models of lung fibrosis. Lung fibrosis is significantly diminished by club cell-specific deletion of Pdcd5 gene. PDCD5 mediates β-catenin/Smad3 complex formation, promoting TGF-β-induced transcriptional activation of matricellular gen ...[more]
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