Estimating the optimal individualized treatment rule from a cost-effectiveness perspective.

ABSTRACT: Optimal individualized treatment rules (ITRs) provide customized treatment recommendations based on subject characteristics to maximize clinical benefit in accordance with the objectives in precision medicine. As a result, there is growing interest in developing statistical tools for estimating optimal ITRs in evidence-based research. In health economic perspectives, policy makers consider the tradeoff between health gains and incremental costs of interventions to set priorities and allocate resources. However, most work on ITRs has focused on maximizing the effectiveness of treatment without considering costs. In this paper, we jointly consider the impact of effectiveness and cost on treatment decisions and define ITRs under a composite-outcome setting, so that we identify the most cost-e

SUBMITTER: Xu Y 

PROVIDER: S-EPMC8134511 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature