Long-term effects of intermittent early life stress on primate prefrontal-subcortical functional connectivity.

ABSTRACT: Correlational studies of humans suggest that exposure to early life stress has long-term effects on neural circuits involved in vulnerability and resilience to mental health disorders. Stress-related mental health disorders are more prevalent in women than in men. Here, female squirrel monkeys are randomized to intermittently stressful (IS) social separations or a non-separated (NS) control condition conducted from 17 to 27 weeks of age. Nine years later in mid-life adulthood, resting-state functional magnetic resonance imaging was employed to parcellate prefrontal cortex (PFC). Resulting subdivisions were then used to characterize functional connectivity within PFC, and between PFC subdivisions and subcortical regions that are known to be altered by stress. Extensive hyper-connectivity of

SUBMITTER: Yuan R 

PROVIDER: S-EPMC8134590 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature