Medial orbitofrontal cortex dopamine D₁/D₂ receptors differentially modulate distinct forms of probabilistic decision-making.

ABSTRACT: Efficient decision-making involves weighing the costs and benefits associated with different actions and outcomes to maximize long-term utility. The medial orbitofrontal cortex (mOFC) has been implicated in guiding choice in situations involving reward uncertainty, as inactivation in rats alters choice involving probabilistic rewards. The mOFC receives considerable dopaminergic input, yet how dopamine (DA) modulates mOFC function has been virtually unexplored. Here, we assessed how mOFC D₁ and D₂ receptors modulate two forms of reward seeking mediated by this region, probabilistic reversal learning and probabilistic discounting. Separate groups of well-trained rats received intra-mOFC microinfusions of selective D₁ or D₂ antagonists or agonists p

SUBMITTER: Jenni NL 

PROVIDER: S-EPMC8134636 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature