Histopathological Definitions of Extranodal Extension: A Systematic Review.

ABSTRACT: Extranodal extension (ENE) is a very strong prognostic factor in head and neck squamous cell carcinoma. However, significant variance in reported incidence of ENE suggests discordance in perception of ENE among pathologists. This study aims to map the different definitions of histopathological ENE used in the literature. A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement. Guided by the research question: "How is histopathological ENE defined?" the databases Medline, Embase, and Cochrane were systematically searched. All retrieved studies were reviewed and qualitatively analyzed. Three categories of existing definitions were formed. The systematic literature search yielded 1786 studies after removal of duplicates.

SUBMITTER: Abdel-Halim CN 

PROVIDER: S-EPMC8134648 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature