PET Neuroimaging of Alzheimer's Disease: Radiotracers and Their Utility in Clinical Research.

ABSTRACT: Alzheimer's Disease (AD), the leading cause of senile dementia, is a progressive neurodegenerative disorder affecting millions of people worldwide and exerting tremendous socioeconomic burden on all societies. Although definitive diagnosis of AD is often made in the presence of clinical manifestations in late stages, it is now universally believed that AD is a continuum of disease commencing from the preclinical stage with typical neuropathological alterations appearing decades prior to its first symptom, to the prodromal stage with slight symptoms of amnesia (amnestic mild cognitive impairment, aMCI), and then to the terminal stage with extensive loss of basic cognitive functions, i.e., AD-dementia. Positron emission tomography (PET) radiotracers have been developed in a search to meet th

SUBMITTER: Bao W 

PROVIDER: S-EPMC8134674 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature