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Effect of Korean Red Ginseng through comparative analysis of cardiac gene expression in db/db mice.

ABSTRACT: Korean Red Ginseng (KRG) is an herbal oriental medicine known to alleviate cardiovascular dysfunction. To analysis the expression of diabetic cardiac complication-associated genes in db/db mice, we studied the cardiac gene expression following KRG treatment. In result, a total of 585 genes were found to be changed in db/db mice. Among the changed expression, 245 genes were found to 2-fold upregulated, and 340 genes were 2-fold downregulated. In addition, the changed gene expressions were ameliorated by KRG. In conclusion, KRG may be possible to normalize cardiac gene expressions in db/db mice.

SUBMITTER: Jang YJ

PROVIDER: S-EPMC8134846 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Effect of Korean Red Ginseng through comparative analysis of cardiac gene expression in db/db mice.

Jang Young-Jin YJ Aravinthan Adithan A Hossain Mohammad Amjad MA Kopalli Spandana Rajendra SR Kim Bumseok B Kim Nam Soo NS Kang Chang-Won CW Kim Jong-Hoon JH

Journal of ginseng research 20200731 3

Korean Red Ginseng (KRG) is an herbal oriental medicine known to alleviate cardiovascular dysfunction. To analysis the expression of diabetic cardiac complication-associated genes in db/db mice, we studied the cardiac gene expression following KRG treatment. In result, a total of 585 genes were found to be changed in db/db mice. Among the changed expression, 245 genes were found to 2-fold upregulated, and 340 genes were 2-fold downregulated. In addition, the changed gene expression ...[more]

PMID: 34025138

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