Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging.

ABSTRACT: MicroRNAs (miRNAs) regulate gene expression and thereby influence cell development and function. Numerous studies have shown the significant roles of miRNAs in regulating immune cells including natural killer (NK) cells. However, little is known about the role of miRNAs in NK cells with aging. We previously demonstrated that the aged C57BL/6 mice have significantly decreased proportion of mature (CD27^- CD11b⁺ ) NK cells compared with young mice, indicating impaired maturation of NK cells with aging. Here, we performed deep sequencing of CD27⁺ NK cells from young and aged mice. Profiling of the miRNome (global miRNA expression levels) revealed that 49 miRNAs displayed a twofold or greater difference in expression between young and aged NK cells. Among these,

SUBMITTER: Lu J 

PROVIDER: S-EPMC8135006 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature