Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging.

ABSTRACT: Cattle are an attractive animal model of fertility in women due to their high degree of similarity relative to follicle selection, embryo cleavage, blastocyst formation, and gestation length. To facilitate future studies of the epigenetic underpinnings of aging effects in the female reproductive axis, several DNA methylation-based biomarkers of aging (epigenetic clocks) for bovine oocytes are presented. One such clock was germane to only oocytes, while a dual-tissue clock was highly predictive of age in both oocytes and blood. Dual species clocks that apply to both humans and cattle were also developed and evaluated. These epigenetic clocks can be used to accurately estimate the biological age of oocytes. Both epigenetic clock studies and epigenome-wide association studies revealed that bl

SUBMITTER: Kordowitzki P 

PROVIDER: S-EPMC8135012 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature