Continuation of Antidepressants vs Sequential Psychological Interventions to Prevent Relapse in Depression: An Individual Participant Data Meta-analysis.

ABSTRACT:

Importance

Depression frequently recurs. To prevent relapse, antidepressant medication is often taken in the long term. Sequentially delivering a psychological intervention while undergoing tapering of antidepressant medication might be an alternative to long-term antidepressant use. However, evidence is lacking on which patients may benefit from tapering antidepressant medication while receiving a psychological intervention and which should continue the antidepressant therapy. A meta-analysis of individual patient data with more power and precision than individual randomized clinical trials or a standard meta-analysis is warranted.

Objectives

To compare the associations between use of a psychological intervention during and/or after antidepressant tapering vs antidepressant

SUBMITTER: Breedvelt JJF 

PROVIDER: S-EPMC8135055 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature