Blood-based biomarkers of human papillomavirus-associated cancers: A systematic review and meta-analysis.

ABSTRACT:

Background

Despite the significant societal burden of human papillomavirus (HPV)-associated cancers, clinical screening interventions for HPV-associated noncervical cancers are not available. Blood-based biomarkers may help close this gap in care.

Methods

Five databases were searched, 5687 articles were identified, and 3631 unique candidate titles and abstracts were independently reviewed by 2 authors; 702 articles underwent a full-text review. Eligibility criteria included the assessment of a blood-based biomarker within a cohort or case-control study.

Results

One hundred thirty-seven studies were included. Among all biomarkers assessed, HPV-16 E seropositivity and circulating HPV DNA were most significantly correlated with HPV-associated cancers in comparison with c

SUBMITTER: Balachandra S 

PROVIDER: S-EPMC8135101 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature