Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism.

ABSTRACT:

Background

Cells adapt their metabolism and activities in response to signals from their surroundings, and this ability is essential for their survival in the face of perturbations. In tissues a deficit of these mechanisms is commonly associated with cellular aging and diseases, such as cardiovascular disease, cancer, immune system decline, and neurological pathologies. Several proteins have been identified as being able to respond directly to energy, nutrient, and growth factor levels and stress stimuli in order to mediate adaptations in the cell. In particular, mTOR, AMPK, and sirtuins are known to play an essential role in the management of metabolic stress and energy balance in mammals.

Methods

To understand the complex interactions of these signalling pathways and envir

SUBMITTER: Sadria M 

PROVIDER: S-EPMC8135154 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature