Protective mechanical ventilation with optimal PEEP during RARP improves oxygenation and pulmonary indexes.

ABSTRACT:

Background

This trial aimed to evaluate the effects of a protective ventilation strategy on oxygenation/pulmonary indexes in patients undergoing robot-assisted radical prostatectomy (RARP) in the steep Trendelenburg position.

Methods

In phase 1, the most optimal positive end-expiratory pressure (PEEP) was determined in 25 patients at 11 cmH₂O. In phase 2, 64 patients were randomized to the traditional ventilation group with tidal volume (VT) of 9 ml/kg of predicted body weight (PBW) and the protective ventilation group with VT of 7 ml/kg of PBW with optimal PEEP and recruitment maneuvers (RMs). The primary endpoint was the intraoperative and postoperative PaO₂/FiO₂. The secondary endpoints were the PaCO₂, SpO₂, modified

SUBMITTER: Zhou J 

PROVIDER: S-EPMC8135157 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature