TMT-based proteomic and bioinformatic analyses of human granulosa cells from obese and normal-weight female subjects.

ABSTRACT:

Background

Increasing evidence supports a relationship between obesity and either infertility or subfertility in women. Most previous omics studies were focused on determining if the serum and follicular fluid expression profiles of subjects afflicted with both obesity-related infertility and polycystic ovary syndrome (PCOS) are different than those in normal healthy controls. As granulosa cells (GCs) are essential for oocyte development and fertility, we determined here if the protein expression profiles in the GCs from obese subjects are different than those in their normal-weight counterpart.

Methods

GC samples were collected from obese female subjects (n = 14) and normal-weight female subjects (n = 12) who were infertile and underwent in vitro fertilization (IVF) treatme

SUBMITTER: Si C 

PROVIDER: S-EPMC8135161 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature