An Exercise Mimetic Approach to Reduce Poststroke Deconditioning and Enhance Stroke Recovery.

ABSTRACT: Evidence supports early rehabilitation after stroke to limit disability. However, stroke survivors are typically sedentary and experience significant cardiovascular and muscular deconditioning. Despite growing consensus that preclinical and clinical stroke recovery research should be aligned, there have been few attempts to incorporate cardiovascular and skeletal muscle deconditioning into animal models of stroke. Here, we demonstrate in rats that a hindlimb sensorimotor cortex stroke results in both cardiovascular and skeletal muscle deconditioning and impairments in gait akin to those observed in humans. To reduce poststroke behavioral, cardiovascular, and skeletal muscle perturbations, we then used a combinatorial intervention consisting of aerobic and resistance exercise in conjunction

SUBMITTER: McDonald MW 

PROVIDER: S-EPMC8135250 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature