Interactions between SARS-CoV-2 and influenza, and the impact of coinfection on disease severity: a test-negative design.

ABSTRACT:

Background

The impact of SARS-CoV-2 alongside influenza is a major concern in the northern hemisphere as winter approaches.

Methods

Test data for influenza and SARS-CoV-2 from national surveillance systems between 20 January 2020 and 25 April 2020 were used to estimate influenza infection on the risk of SARS-CoV-2 infection. A test-negative design was used to assess the odds of SARS-CoV-2 in those who tested positive for influenza compared with those who tested negative. The severity of SARS-CoV-2 was also assessed using univariable and multivariable analyses.

Results

The risk of testing positive for SARS-CoV-2 was 58% lower among influenza-positive cases and patients with a coinfection had a risk of death of 5.92 (95% confidence interval: 3.21-10.91) times greater th

SUBMITTER: Stowe J 

PROVIDER: S-EPMC8135706 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature