The statistical approach in trial-based economic evaluations matters: get your statistics together!

ABSTRACT:

Background

Baseline imbalances, skewed costs, the correlation between costs and effects, and missing data are statistical challenges that are often not adequately accounted for in the analysis of cost-effectiveness data. This study aims to illustrate the impact of accounting for these statistical challenges in trial-based economic evaluations.

Methods

Data from two trial-based economic evaluations, the REALISE and HypoAware studies, were used. In total, 14 full cost-effectiveness analyses were performed per study, in which the four statistical challenges in trial-based economic evaluations were taken into account step-by-step. Statistical approaches were compared in terms of the resulting cost and effect differences, ICERs, and probabilities of cost-effectiveness.

Results

SUBMITTER: Mutubuki EN 

PROVIDER: S-EPMC8135982 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature