Effectiveness of matching human leukocyte antigens (HLA) in corneal transplantation: a systematic review protocol.

ABSTRACT:

Background

Corneal transplantation is the most frequently performed transplantation in the UK. Despite this, the therapeutic value of matching human leukocyte antigen (HLA) subtypes for transplanted corneas remains controversial. Ocular immune privilege was originally deemed to render matching unnecessary; however, more recently, matching has demonstrated improved outcomes including graft success, amongst others. This systematic review aims to evaluate the effectiveness of major and minor antigen matching on graft outcomes in corneal transplantation.

Methods

Standard systematic review methodology will be used to identify, select and extract data from observational studies and clinical trials assessing the effects of HLA matching on corneal graft outcomes. Bibliographic datab

SUBMITTER: Sachdeva GS 

PROVIDER: S-EPMC8136040 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature