Heterogeneity in design and analysis of ICU delirium randomized trials: a systematic review.

ABSTRACT:

Background

There is a growing number of randomized controlled trials (RCTs) evaluating interventions to prevent or treat delirium in the intensive care unit (ICU). Efforts to improve the conduct of delirium RCTs are underway, but none address issues related to statistical analysis. The purpose of this review is to evaluate heterogeneity in the design and analysis of delirium outcomes and advance methodological recommendations for delirium RCTs in the ICU.

Methods

Relevant databases, including PubMed and Embase, were searched with no restrictions on language or publication date; the search was conducted on July 8, 2019. RCTs conducted on adult ICU patients with delirium as the primary outcome were included where trial results were available. Data on frequency and duration of

SUBMITTER: Colantuoni E 

PROVIDER: S-EPMC8136095 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature