Reconfigurable Microphysiological Systems for Modeling Innervation and Multitissue Interactions.

ABSTRACT: Tissue-engineered models continue to experience challenges in delivering structural specificity, nutrient delivery, and heterogenous cellular components, especially for organ-systems that require functional inputs/outputs and have high metabolic requirements, such as the heart. While soft lithography has provided a means to recapitulate complex architectures in the dish, it is plagued with a number of prohibitive shortcomings. Here, concepts from microfluidics, tissue engineering, and layer-by-layer fabrication are applied to develop reconfigurable, inexpensive microphysiological systems that facilitate discrete, 3D cell compartmentalization, and improved nutrient transport. This fabrication technique includes the use of the meniscus pinning effect, photocrosslinkable hydrogels, and a comm

SUBMITTER: Soucy JR 

PROVIDER: S-EPMC8136149 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature