Defining the lineage of thermogenic perivascular adipose tissue.

ABSTRACT: Brown adipose tissue can expend large amounts of energy, and therefore increasing its size or activity is a promising therapeutic approach to combat metabolic disease. In humans, major deposits of brown fat cells are found intimately associated with large blood vessels, corresponding to perivascular adipose tissue (PVAT). However, the cellular origins of PVAT are poorly understood. Here, we determine the identity of perivascular adipocyte progenitors in mice and humans. In mice, thoracic PVAT develops from a fibroblastic lineage, consisting of progenitor cells (Pdgfra⁺, Ly6a⁺ and Pparg^-) and preadipocytes (Pdgfra⁺, Ly6a⁺ and Pparg⁺), which share transcriptional similarity with analogous cell types in white adipose tissue. In

SUBMITTER: Angueira AR 

PROVIDER: S-EPMC8136151 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature