The effect of normal, metaplastic, and neoplastic esophageal extracellular matrix upon macrophage activation.

ABSTRACT:

Introduction

Macrophages are capable of extreme plasticity and their activation state has been strongly associated with solid tumor growth progression and regression. Although the macrophage response to extracellular matrix (ECM) isolated from normal tissue is reasonably well understood, there is a relative dearth of information regarding their response to ECM isolated from chronically inflamed tissues, pre-neoplastic tissues, and neoplastic tissues. Esophageal adenocarcinoma (EAC) is a type of neoplasia driven by chronic inflammation in the distal esophagus, and the length of the esophagus provides the opportunity to investigate macrophage behavior in the presence of ECM isolated from a range of disease states within the same organ.

Methods

Normal, metaplastic, and neoplast

SUBMITTER: Saldin LT 

PROVIDER: S-EPMC8136242 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature