Safety of in-utero antiretroviral exposure: neurologic outcomes in children who are HIV-exposed but uninfected.

ABSTRACT:

Objective

To evaluate whether there is an increased risk of neurologic diagnoses in children who are HIV-exposed but uninfected (CHEU) exposed in utero to specific antiretroviral medications.

Design

Prospective cohort study of CHEU enrolled from 2007 to 2017.

Methods

We evaluated children for neurologic case status, including microcephaly, febrile seizures, seizure disorders, ophthalmologic disorders, and other neurologic disorders. Adjusted relative risks (aRRs) were estimated for the association between in-utero antiretroviral exposure and neurologic case using log-binomial regression, accounting for potential confounders. Sensitivity analyses were conducted to evaluate robustness of findings.

Results

Among 3747 eligible CHEU, 231 (6.2%) met neurologic case c

SUBMITTER: Crowell CS 

PROVIDER: S-EPMC8136420 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature