Regulation of the redox metabolome and thiol proteome by hydrogen sulfide.

ABSTRACT: Overproduction of reactive oxygen species and compromised antioxidant defenses perturb intracellular redox homeostasis and is associated with a myriad of human diseases as well as with the natural process of aging. Hydrogen sulfide (H₂S), which is biosynthesized by organisms ranging from bacteria to man, influences a broad range of physiological functions. A highly touted molecular mechanism by which H₂S exerts its cellular effects is via post-translational modification of the thiol redox proteome, converting cysteine thiols to persulfides, in a process referred to as protein persulfidation. The physiological relevance of this modification in the context of specific signal transmission pathways remains to be rigorously established, while a general protective role for

SUBMITTER: Kumar R 

PROVIDER: S-EPMC8136436 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature