Asbestos bodies count and morphometry in bulk lung tissue samples by non-invasive X-ray micro-tomography.

ABSTRACT: The number of the Asbestos Bodies (AB), i.e. asbestos that developed an iron-protein coating during its permanence in biological tissues, is one of the most accessible markers of asbestos exposure in individuals. The approaches developed to perform AB count in biological tissues are based on the manual examination of tissue digests or histological sections by means of light or electron microscopies. Although these approaches are well established and relatively accessible, manual examination is time-consuming and can be reader-dependent. Besides, approximations are applied because of the limitations of 2D readings and to speed up manual counts. In addition, sample preparation using tissue digests require an amount of tissue that can only be obtained by invasive surgery or post-mortem sampli

SUBMITTER: Bardelli F 

PROVIDER: S-EPMC8136473 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature