Targeted neuromodulation of pelvic floor nerves in aging and multiparous rabbits improves continence.

ABSTRACT: Pelvic floor muscle stretch injury during pregnancy and birth is associated with the incidence of stress urinary incontinence (SUI), a condition that affects 30-60% of the female population and is characterized by involuntary urine leakage during physical activity, further exacerbated by aging. Aging and multiparous rabbits suffer pelvic nerve and muscle damage, resulting in alterations in pelvic floor muscular contraction and low urethral pressure, resembling SUI. However, the extent of nerve injury is not fully understood. Here, we used electron microscopy analysis of pelvic and perineal nerves in multiparous rabbits to describe the extent of stretch nerve injury based on axon count, axon size, myelin-to-axon ratio, and elliptical ratio. Compared to young nulliparous controls, mid-age mu

SUBMITTER: Hernandez-Reynoso AG 

PROVIDER: S-EPMC8136474 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature