Genome-Scale Profiling Reveals Noncoding Loci Carry Higher Proportions of Concordant Data.

ABSTRACT: Many evolutionary relationships remain controversial despite whole-genome sequencing data. These controversies arise, in part, due to challenges associated with accurately modeling the complex phylogenetic signal coming from genomic regions experiencing distinct evolutionary forces. Here, we examine how different regions of the genome support or contradict well-established relationships among three mammal groups using millions of orthologous parsimony-informative biallelic sites (PIBS) distributed across primate, rodent, and Pecora genomes. We compared PIBS concordance percentages among locus types (e.g. coding sequences (CDS), introns, intergenic regions), and contrasted PIBS utility over evolutionary timescales. Sites derived from noncoding sequences provided more data and proportionally

SUBMITTER: Literman R 

PROVIDER: S-EPMC8136493 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature