Structural coordinates: A novel approach to predict protein backbone conformation.

ABSTRACT:

Motivation

Local protein structure is usually described via classifying each peptide to a unique class from a set of pre-defined structures. These classifications may differ in the number of structural classes, the length of peptides, or class attribution criteria. Most methods that predict the local structure of a protein from its sequence first rely on some classification and only then proceed to the 3D conformation assessment. However, most classification methods rely on homologous proteins' existence, unavoidably lose information by attributing a peptide to a single class or suffer from a suboptimal choice of the representative classes.

Results

To alleviate the above challenges, we propose a method that constructs a peptide's structural representation from the sequence,

SUBMITTER: Milchevskaya V 

PROVIDER: S-EPMC8136669 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature