G-Quadruplexes as pathogenic drivers in neurodegenerative disorders.

ABSTRACT: G-quadruplexes (G4s), higher-order DNA and RNA secondary structures featuring guanine-rich nucleic acid sequences with various conformations, are widely distributed in the human genome. These structural motifs are known to participate in basic cellular processes, including transcription, splicing, and translation, and their functions related to health and disease are becoming increasingly recognized. In this review, we summarize the landscape of G4s involved in major neurodegenerative disorders, describing the genes that contain G4-forming sequences and proteins that have high affinity for G4-containing elements. The functions of G4s are diverse, with potentially protective or deleterious effects in the pathogenic cascades of various neurological diseases. While the studies of the function

SUBMITTER: Wang E 

PROVIDER: S-EPMC8136783 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature